Place bread cubes in a lightly greased 9x13 inch baking dish. In a large bowl, beat cream cheese with an electric mixer at medium speed until smooth. Add eggs one at a time, mixing well after each addition.
Stir in milk, half and half, maple syrup, and vanilla until mixture is smooth. Pour cream cheese mixture over top of bread; cover and refrigerate overnight.
Remove souffle from refrigerator, and let stand at room temperature for 30 minutes.
Bake at 375 degrees F. for 30 minutes, or until set. Sprinkle with powdered sugar and serve warm.