In a large skillet, cook the beef until no longer pink; drain. Prepare macaroni and cheese according to package directions.
Spread one can of pizza sauce into a greased 13-in. x 9-in. baking dish; layer with half the beef, macaroni and cheese, and cheddar and mozzarella cheeses. Repeat layers (dish will be full). Bake, uncovered, at 350° for 30-35 minutes or until bubbly.